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Study Information
Study Attribute Value
CEBS Accession Number: 002-02393-0011-0000-1
Chemical Name: Melamine
CASRN: 108-78-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 951364_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 05/10/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.99 ± 0.394
Test Chemical Melamine 
87.5       
 4 5.58 ± 0.528
  
175         
 3 6.68 ± 0.364
  
350         
 4 5.80 ± 0.299
Positive Control Dimethylbenzanthracene 
2.5       
 4 7.03 ± 0.335


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 09/07/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.36 ± 0.148
Test Chemical Melamine 
200         
 4 4.79 ± 0.151
  
400         
 4 4.50 ± 0.228
  
800         
 4 5.86 ± 0.595
Positive Control Dimethylbenzanthracene 
2.5       
 4 15.06 ± 1.834


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/05/89 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 3.54 ± 0.247
Test Chemical Melamine 
87.5       
 4 6.09 ± 0.667
  
175         
 4 4.38 ± 0.231
  
350         
 4 7.58 ± 1.393
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.57 ± 1.101


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed