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Study Information
Study Attribute Value
CEBS Accession Number: 002-02395-0002-0000-3
Chemical Name: Melphalan
CASRN: 148-82-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 283792_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 11/20/1985    Harvest Time: 17 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Melphalan 
1.6       
 50 42 0.840 50.0 12 0.240 24.0 20 0.400 32.0 10 0.200 1.0 
3         
 50 77 1.540 72.0 40 0.800 58.0 37 0.740 48.0 0 0.000 0.0 
5         
 50 105 2.100 88.0 42 0.840 62.0 53 1.060 76.0 10 0.200 1.0
Positive Control: Mitomycin-C 
 0.0625    
 200 53 0.265 22.5 28 0.140 13.0 25 0.125 11.0 0 0.000 0.0
Mitomycin-C 
 0.125     
 50 37 0.740 58.0 23 0.460 40.0 14 0.280 24.0 0 0.000 0.0
Trend: 14.312 11.970 12.513  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/31/1985    Harvest Time: 18 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Melphalan 
1.6       
 200 93 0.465 39.0 34 0.170 16.0 59 0.295 28.0 0 0.000 0.0 
3         
 200 189 0.945 54.5 66 0.330 28.0 93 0.465 36.0 30 0.150 3.0 
5         
 200 255 1.275 71.5 110 0.550 40.5 135 0.675 51.5 10 0.050 1.0
Positive Control: Cyclophosphamide 
5         
 200 136 0.680 40.0 60 0.300 22.5 76 0.380 25.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 85 1.700 78.0 31 0.620 48.0 44 0.880 56.0 10 0.200 1.0
Trend: 14.477 10.061 11.197  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 10/29/1985    Harvest Time: 17 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Melphalan 
1.6       
 200 187 0.935 64.0 69 0.345 28.5 118 0.590 48.0 0 0.000 0.0 
3         
 200 327 1.635 77.0 118 0.590 45.5 189 0.945 60.0 20 0.100 2.0 
5         
 200 445 2.225 87.0 212 1.060 66.5 223 1.115 66.5 10 0.050 1.0
Positive Control: Mitomycin-C 
 0.03      
 200 22 0.110 10.5 7 0.035 3.5 15 0.075 7.5 0 0.000 0.0
Mitomycin-C 
 0.0625    
 50 18 0.360 30.0 9 0.180 18.0 9 0.180 16.0 0 0.000 0.0
Trend: 17.391 14.325 13.351  
Probability: 0.000 0.000 0.000