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Study Information
Study Attribute Value
CEBS Accession Number: 002-02395-0031-0000-5
Chemical Name: Melphalan
CASRN: 148-82-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 141321_CA
Study Result: Positive (Nonstandard Protocol)

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/23/85 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
200         
 8 11.75 ± 2.43 0.0000
Test Chemical Melphalan 
2.5       
 8 26.75 ± 3.87 0.0000
  
5         
 8 40.00 ± 2.65 0.0000
  
10         
 7 43.71 ± 5.75 0.0000
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.73 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed