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Study Information
Study Attribute Value
CEBS Accession Number: 002-02398-0001-0000-5
Chemical Name: Mercuric chloride
CASRN: 7487-94-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 700546_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 05/04/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1027 501 0.488 10.02 25.6 0.000
Test Chemical Mercuric chloride 
3.5       
 50 1020 523 0.513 10.46 25.6 5.108 
6         
 50 1028 579 0.563 11.58 25.6 15.456
Positive Control Mitomycin-C 
 0.01      
 5 100 182 1.820 36.40 25.6 273.082
Trend: 2.367        
Probability: 0.009        

Trial #: 2    Activation: No Activation    Date: 06/01/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 439 0.426 8.78 25.5 0.000
Test Chemical Mercuric chloride 
3         
 50 1042 432 0.415 8.64 25.5 -2.633 
4         
 50 1035 436 0.421 8.72 25.5 -1.067 
5         
 50 1031 464 0.450 9.28 30.3 5.695 
7         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
1         
 50 1026 579 0.564 11.58 25.5 32.533
Mitomycin-C 
10         
 5 105 203 1.933 40.60 25.5 354.047
Trend: 0.821        
Probability: 0.206        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/04/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 480 0.467 9.60 25.6 0.000
Test Chemical Mercuric chloride 
3         
 50 1020 517 0.507 10.34 25.6 8.553 
8         
 50 1018 596 0.585 11.92 25.6 25.386
Positive Control Cyclophosphamide 
2         
 5 101 194 1.921 38.80 25.6 311.370
Trend: 3.717        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/01/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 417 0.400 8.34 25.5 0.000
Test Chemical Mercuric chloride 
5         
 50 1037 445 0.429 8.90 25.5 7.229 
7         
 50 1044 428 0.410 8.56 25.5 2.441 
8.9       
 50 1034 497 0.481 9.94 25.5 20.107 
11         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1039 576 0.554 11.52 25.5 38.528
Cyclophosphamide 
2         
 5 104 174 1.673 34.80 25.5 318.069
Trend: 2.324        
Probability: 0.010