COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02398-0002-0000-6
Chemical Name: Mercuric chloride
CASRN: 7487-94-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 700546_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 07/07/1983    Harvest Time: 20.8 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Mercuric chloride
6.03      
100 23 0.230 8.0 7 0.070 6.0 6 0.060 3.0 10 0.100 1.0
7.02      
100 49 0.490 20.0 14 0.140 11.0 15 0.150 13.0 20 0.200 2.0
8.04      
100 89 0.890 39.0 41 0.410 31.0 48 0.480 25.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.05      
50 16 0.320 24.0 6 0.120 12.0 10 0.200 16.0 0 0.000 0.0
Trend: 7.701 6.696 6.253  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/21/1983    Harvest Time: 10.7 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Mercuric chloride
5.01      
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
7.47      
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
10.01      
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
12.45      
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
25         
50 9 0.180 10.0 6 0.120 6.0 3 0.060 4.0 0 0.000 0.0
Trend: -1.304 -1.304 0.000  
Probability: 0.904 0.904 0.000  


Trial #:2   Activation: No Activation    Date: 06/21/1983    Harvest Time: 10.7 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Mercuric chloride
3.98      
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
6.03      
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
7.95      
100 10 0.100 7.0 3 0.030 3.0 7 0.070 7.0 0 0.000 0.0
10.05      
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.5       
50 13 0.260 22.0 6 0.120 10.0 7 0.140 10.0 0 0.000 0.0
Trend: 2.681 2.234 2.681  
Probability: 0.004 0.013 0.004