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Study Information
Study Attribute Value
CEBS Accession Number: 002-02398-0009-0000-3
Chemical Name: Mercuric chloride
CASRN: 7487-94-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 289120
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 61# 101 103.5 56 46
    68# 92 93 46
    70 104 87 42
    79 103 92 39
Test Chemical Mercuric chloride 
 0.1       
 60# 56 75 42 36
    66 53 60 30
  
 0.2       
 68 51 141 69 67
    56 47 107 64
  
 0.4       
 63 19 156 83 84*
    62 23 159 86
  
 0.8       
 46 7 305 222 215*
    48 6 299 208
  
1.6       
   
Positive Control Methyl Methane Sulfonate 
15         
 28 22 258 311 285*
    24 16 183 260

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 71# 95 97 46 54
    85# 109 160.5 63
    83 95 129 52
Test Chemical Mercuric chloride 
 0.2107    
 66# 37 184.5 93 85*
    85# 45 196.5 77
  
 0.316     
 74 49 140 63 53
    106# 50 135 42
  
 0.4741    
 69# 21 128 62 53
    103# 33 136.5 44
  
 0.7111    
 67 13 201 100
  
1.067     
 75# 12 217 96 99*
    73# 10 222 102
  
1.6       
   
Positive Control Methyl Methane Sulfonate 
15         
 20# 20 199.5 333 333*

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 70# 89 111 53 49
    79# 112 85.5 36
    54# 99 94.5 58
Test Chemical Mercuric chloride 
 0.1       
 56# 65 97.5 59 57
    60# 58 100 56
  
 0.3       
 59 39 111 62 53
    52# 36 69 44
  
 0.5       
 61# 20 220.5 121 121*
    60 13 217 121
  
 0.7       
 64# 22 207 108
  
 0.9       
 65 9 276 141
Positive Control Methyl Methane Sulfonate 
15         
 17 16 236 467 467*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination