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Study Information
Study Attribute Value
CEBS Accession Number: 002-02429-0001-0000-0
Chemical Name: Methyl carbamate
CASRN: 598-55-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 732171_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Questionable 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/13/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 344 0.328 6.88 26.5 -7.737
Medium 
0         
 50 1040 370 0.356 7.40 26.5 0.000
Test Chemical Methyl carbamate 
160         
 50 1037 395 0.381 7.90 26.5 7.066 
500         
 50 1031 403 0.391 8.06 26.5 9.870 
1600         
 50 1024 360 0.352 7.20 26.5 -1.182 
5000         
 50 1039 423 0.407 8.46 26.5 14.434
Positive Control Mitomycin-C 
 0.01      
 50 1038 2539 2.446 50.78 26.5 587.538
Trend: 1.220        
Probability: 0.111        

Trial #: 2    Activation: No Activation    Date: 03/19/1983    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1038 360 0.347 7.20 26.0 -5.221
Medium 
0         
 50 1033 378 0.366 7.56 26.0 0.000
Test Chemical Methyl carbamate 
2000         
 50 1036 355 0.343 7.10 26.0 -6.357 
3000         
 50 1030 389 0.378 7.78 26.0 3.210 
4000         
 50 1014 422 0.416 8.44 26.0 13.732 
5000         
 50 1043 430 0.412 8.60 26.0 12.666
Positive Control Mitomycin-C 
 0.005     
 50 1039 1301 1.252 26.02 26.0 242.192
Trend: 2.759        
Probability: 0.003        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/13/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1039 329 0.317 6.58 26.5 -13.851
Medium 
0         
 50 1042 383 0.368 7.66 26.5 0.000
Test Chemical Methyl carbamate 
160         
 50 1042 392 0.376 7.84 26.5 2.350 
500         
 50 1042 374 0.359 7.48 26.5 -2.350 
1600         
 50 1044 377 0.361 7.54 26.5 -1.755 
5000         
 50 1040 371 0.357 7.42 26.5 -2.947
Positive Control Cyclophosphamide 
1.5       
 50 1052 1123 1.067 22.46 26.5 190.424
Trend: -0.621        
Probability: 0.733        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/19/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1034 360 0.348 7.20 26.0 -16.823
Medium 
0         
 50 1044 437 0.419 8.74 26.0 0.000
Test Chemical Methyl carbamate 
2000         
 50 1039 407 0.392 8.14 26.0 -6.417 
3000         
 50 1039 354 0.341 7.08 26.0 -18.603 
4000         
 50 1046 397 0.380 7.94 26.0 -9.327 
5000         
 50 1049 369 0.352 7.38 26.0 -15.963
Positive Control Cyclophosphamide 
1.5       
 50 1042 1430 1.372 28.60 26.0 227.859
Trend: -2.529        
Probability: 0.994