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Study Information
Study Attribute Value
CEBS Accession Number: 002-02432-0001-0000-4
Chemical Name: Methyl dopa
CASRN: 555-30-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 003933_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/06/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1022 423 0.414 8.46 25.5 0.000
Test Chemical Methyl dopa 
3.5       
 50 1039 425 0.409 8.50 25.5 -1.171 
11.7       
 50 1042 482 0.463 9.64 25.5 11.761 
35         
 50 1034 459 0.444 9.18 25.5 7.251 
116.7       
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1039 537 0.517 10.74 25.5 24.873
Mitomycin-C 
 0.01      
 5 105 230 2.190 46.00 25.5 429.236
Trend: 1.593        
Probability: 0.056        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/06/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 421 0.404 8.42 25.5 0.000
Test Chemical Methyl dopa 
350         
 50 1047 394 0.376 7.88 25.5 -6.860 
1200         
 50 1044 417 0.399 8.34 25.5 -1.140 
3500         
 50 1047 434 0.415 8.68 25.5 2.596
Positive Control Cyclophosphamide 
 0.4       
 50 1042 664 0.637 13.28 25.5 57.720
Cyclophosphamide 
2         
 5 104 184 1.769 36.80 25.5 337.895
Trend: 0.624        
Probability: 0.266