COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02432-0001-0000-4
Chemical Name: Methyl dopa
CASRN: 555-30-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 003933_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/06/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1022 423 0.414 8.46 25.5 0.000
Test Chemical Methyl dopa 
3.5       
 50 1039 425 0.409 8.50 25.5 -1.171 
11.7       
 50 1042 482 0.463 9.64 25.5 11.761 
35         
 50 1034 459 0.444 9.18 25.5 7.251 
116.7       
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1039 537 0.517 10.74 25.5 24.873
Mitomycin-C 
 0.01      
 5 105 230 2.190 46.00 25.5 429.236
Trend: 1.593        
Probability: 0.056        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/06/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 421 0.404 8.42 25.5 0.000
Test Chemical Methyl dopa 
350         
 50 1047 394 0.376 7.88 25.5 -6.860 
1200         
 50 1044 417 0.399 8.34 25.5 -1.140 
3500         
 50 1047 434 0.415 8.68 25.5 2.596
Positive Control Cyclophosphamide 
 0.4       
 50 1042 664 0.637 13.28 25.5 57.720
Cyclophosphamide 
2         
 5 104 184 1.769 36.80 25.5 337.895
Trend: 0.624        
Probability: 0.266