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Study Information
Study Attribute Value
CEBS Accession Number: 002-02433-0001-0000-5
Chemical Name: Methyl ethyl ketone
CASRN: 78-93-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 036259_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/20/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1048 392 0.374 7.84 25.6 0.000
Test Chemical Methyl ethyl ketone 
500         
 50 1048 368 0.351 7.36 25.6 -6.122 
1666.7       
 50 1045 394 0.377 7.88 25.6 0.799 
5000         
 50 1046 489 0.467 9.78 34.0 24.983
Positive Control Mitomycin-C 
 0.001     
 50 1041 517 0.497 10.34 25.5 32.775
Mitomycin-C 
 0.01      
 5 105 201 1.914 40.20 25.6 411.778
Trend: 3.503        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 12/03/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 407 0.389 8.14 25.5 0.000
Test Chemical Methyl ethyl ketone 
3000         
 50 1044 347 0.332 6.94 25.5 -14.497 
4000         
 50 1036 421 0.406 8.42 25.5 4.538 
5000         
 50 1041 445 0.427 8.90 34.7 9.967
Positive Control Mitomycin-C 
 0.001     
 50 1046 545 0.521 10.90 25.5 34.035
Mitomycin-C 
 0.01      
 5 105 181 1.724 36.20 25.5 343.447
Trend: 2.220        
Probability: 0.013        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/20/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1045 449 0.430 8.98 25.6 0.000
Test Chemical Methyl ethyl ketone 
500         
 50 1042 416 0.399 8.32 25.6 -7.083 
1666.7       
 50 1045 394 0.377 7.88 25.6 -12.249 
5000         
 50 1047 409 0.391 8.18 25.6 -9.083
Positive Control Cyclophosphamide 
 0.4       
 50 1041 741 0.712 14.82 25.6 65.668
Cyclophosphamide 
2         
 5 104 252 2.423 50.40 25.6 463.946
Trend: -1.609        
Probability: 0.946