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Study Information
Study Attribute Value
CEBS Accession Number: 002-02433-0002-0000-6
Chemical Name: Methyl ethyl ketone
CASRN: 78-93-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 036259_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 12/11/1985    Harvest Time: 20 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 200 4 0.020 0.5 0 0.000 0.0 4 0.020 0.5 0 0.000 0.0
Test Chemical: Methyl ethyl ketone 
2500         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
3750         
 200 4 0.020 1.5 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
5000         
 200 8 0.040 3.5 4 0.020 2.0 4 0.020 1.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 59 0.295 23.5 26 0.130 12.0 33 0.165 13.5 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 20 0.800 56.0 15 0.600 44.0 5 0.200 16.0 0 0.000 0.0
Trend: 2.110 2.128 1.067  
Probability: 0.017 0.017 0.143  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/11/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Medium 
0         
 200 5 0.025 2.5 3 0.015 1.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: Methyl ethyl ketone 
2500         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
3750         
 200 3 0.015 1.5 1 0.005 0.5 1 0.005 0.5 1 0.005 0.5 
5000         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 25 15 0.600 48.0 7 0.280 28.0 8 0.320 28.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 8 0.320 24.0 2 0.080 8.0 6 0.240 20.0 0 0.000 0.0
Trend: -0.624 -0.390 -0.750  
Probability: 0.734 0.652 0.773