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Study Information
Study Attribute Value
CEBS Accession Number: 002-02434-0001-0000-6
Chemical Name: Methyl ethyl ketone peroxide
CASRN: 1338-23-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 774268_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 05/24/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 406 0.387 8.12 26.0 -11.992
Dimethyl Sulfoxide 
0         
 50 1046 460 0.440 9.20 26.0 0.000
Test Chemical Methyl ethyl ketone peroxide 
 0.5       
 50 1050 489 0.466 9.78 26.0 5.899 
1.6       
 50 1042 529 0.508 10.58 26.0 15.441 
5         
 50 1050 519 0.494 10.38 26.0 12.396 
16         
 50 1048 644 0.615 12.88 26.0 39.733 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1051 1317 1.253 26.34 26.0 184.942
Mitomycin-C 
 0.01      
 10 209 619 2.962 61.90 26.0 573.470
Trend: 5.453        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/19/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 450 0.430 9.00 26.5 0.000
Negative (Not Specified) 
0         
 50 1049 424 0.404 8.48 26.5 -5.957
Test Chemical Methyl ethyl ketone peroxide 
2         
 50 1049 447 0.426 8.94 26.5 -0.856 
5         
 50 1048 497 0.474 9.94 26.5 10.339 
10         
 50 1048 591 0.564 11.82 26.5 31.208 
15         
 50 1051 657 0.625 13.14 26.5 45.444 
20         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1049 2115 2.016 42.30 26.5 369.104
Mitomycin-C 
 0.01      
 10 210 648 3.086 64.80 26.5 617.943
Trend: 7.525        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/24/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1037 395 0.381 7.90 26.0 -8.124
Dimethyl Sulfoxide 
0         
 50 1042 432 0.415 8.64 26.0 0.000
Test Chemical Methyl ethyl ketone peroxide 
1.6       
 50 1046 463 0.443 9.26 26.0 6.766 
5         
 50 1042 461 0.442 9.22 26.0 6.713 
16         
 50 1046 460 0.440 9.20 26.0 6.074 
50         
 50 1039 615 0.592 12.30 26.0 42.772 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1040 701 0.674 14.02 26.0 62.581
Cyclophosphamide 
2         
 10 209 339 1.622 33.90 26.0 291.235
Trend: 5.245        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/19/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 461 0.442 9.22 26.0 0.000
Negative (Not Specified) 
0         
 50 1046 483 0.462 9.66 26.0 4.372
Test Chemical Methyl ethyl ketone peroxide 
10         
 50 1038 441 0.425 8.82 26.0 -3.970 
25         
 50 1042 487 0.467 9.74 26.0 5.640 
50         
 50 1044 581 0.557 11.62 26.0 25.789 
100         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1049 712 0.679 14.24 26.0 53.416
Cyclophosphamide 
2         
 10 209 394 1.885 39.40 26.0 326.105
Trend: 3.990        
Probability: 0.000