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Study Information
Study Attribute Value
CEBS Accession Number: 002-02435-0001-0000-7
Chemical Name: Methyl ethyl ketoxime
CASRN: 96-29-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 497671_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/28/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1029 386 0.375 7.72 25.5 0.000
Test Chemical Methyl ethyl ketoxime 
16.7       
 50 1025 376 0.367 7.52 25.5 -2.211 
50         
 50 1045 423 0.405 8.46 25.5 7.908 
166.7       
 50 1020 438 0.429 8.76 25.5 14.473 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1035 540 0.522 10.80 25.5 39.085
Mitomycin-C 
 0.01      
 5 104 174 1.673 34.80 25.5 346.009
Trend: 2.291        
Probability: 0.011        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/28/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 428 0.412 8.56 25.5 0.000
Test Chemical Methyl ethyl ketoxime 
500         
 50 1018 357 0.351 7.14 25.5 -14.868 
1666.7       
 50 1016 395 0.389 7.90 25.5 -5.621 
5000         
 50 1026 415 0.404 8.30 25.5 -1.809
Positive Control Cyclophosphamide 
 0.4       
 50 1025 602 0.587 12.04 25.5 42.575
Cyclophosphamide 
2         
 5 103 154 1.495 30.80 25.5 262.957
Trend: 0.166        
Probability: 0.434