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Study Information
Study Attribute Value
CEBS Accession Number: 002-02435-0002-0000-8
Chemical Name: Methyl ethyl ketoxime
CASRN: 96-29-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 497671_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Test Failure 

Trial #:1   Activation: No Activation    Date: 07/02/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0
Test Chemical: Methyl ethyl ketoxime 
1873         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
2497         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0 
3727         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
5000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 31 0.155 12.5 16 0.080 7.5 15 0.075 6.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 9 0.360 36.0 4 0.160 16.0 5 0.200 20.0 0 0.000 0.0
Trend: -1.211 0.069 -1.345  
Probability: 0.887 0.472 0.911  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/17/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 6 0.030 2.5 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 6 0.030 2.5 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: Methyl ethyl ketoxime 
2513         
 200 6 0.030 2.5 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0 
3750         
 200 8 0.040 3.0 4 0.020 2.0 4 0.020 1.5 0 0.000 0.0 
5000         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 32 0.160 11.5 13 0.065 4.0 19 0.095 7.5 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 13 0.520 44.0 4 0.160 16.0 9 0.360 32.0 0 0.000 0.0
Trend: -0.166 -0.063 -0.493  
Probability: 0.566 0.525 0.689  


Trial #:2   Activation: No Activation    Date: 06/17/1986    Harvest Time: 20 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 5 0.025 2.0 0 0.000 0.0 5 0.025 2.0 0 0.000 0.0
Test Chemical: Methyl ethyl ketoxime 
2500         
 200 7 0.035 3.5 0 0.000 0.0 7 0.035 3.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.08      
 25 11 0.440 28.0 4 0.160 12.0 7 0.280 20.0 0 0.000 0.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000