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Study Information
Study Attribute Value
CEBS Accession Number: 002-02442-0001-0000-5
Chemical Name: Methyl methacrylate
CASRN: 80-62-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 864485_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/14/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1041 321 0.308 6.42 26.0 3.449
Dimethyl Sulfoxide 
0         
 50 1040 310 0.298 6.20 26.0 0.000
Test Chemical Methyl methacrylate 
5         
 50 1045 366 0.350 7.32 26.0 17.500 
16         
 50 1048 394 0.376 7.88 26.0 26.127 
50         
 50 1045 430 0.411 8.60 26.0 38.046 
160         
 50 1047 459 0.438 9.18 26.0 47.075 
500         
 50 1040 514 0.494 10.28 26.0 65.806 
1600         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.003     
 50 1049 854 0.814 17.08 26.0 173.120
Mitomycin-C 
 0.005     
 50 1050 1131 1.077 22.62 26.0 261.364
Trend: 7.860        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/18/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 414 0.396 8.28 26.0 1.373
Dimethyl Sulfoxide 
0         
 50 1044 408 0.391 8.16 26.0 0.000
Test Chemical Methyl methacrylate 
750         
 50 1045 537 0.514 10.74 26.0 31.492 
1000         
 50 1048 600 0.573 12.00 31.0 46.498 
1250         
 50 1046 718 0.686 14.36 31.0 75.644
Positive Control Mitomycin-C 
 0.005     
 50 1048 1480 1.412 29.60 26.0 261.361
Mitomycin-C 
 0.005     
 50 1047 1561 1.491 31.22 26.0 281.502
Trend: 9.243        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/14/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 459 0.436 9.18 27.0 0.000
Negative (Not Specified) 
0         
 50 1048 446 0.426 8.92 27.0 -2.461
Test Chemical Methyl methacrylate 
50         
 50 1048 471 0.449 9.42 27.0 3.006 
160         
 50 1049 431 0.411 8.62 27.0 -5.832 
500         
 50 1038 429 0.413 8.58 27.0 -5.275 
1600         
 50 1046 444 0.424 8.88 27.0 -2.713 
5000         
 50 1048 613 0.585 12.26 27.0 34.061
Positive Control Cyclophosphamide 
1.5       
 50 1050 1148 1.093 22.96 27.0 150.585
Cyclophosphamide 
1.5       
 50 1048 1159 1.106 23.18 27.0 153.469
Trend: 3.847        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/18/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1034 365 0.353 7.30 26.0 -0.127
Dimethyl Sulfoxide 
0         
 50 1044 369 0.353 7.38 26.0 0.000
Test Chemical Methyl methacrylate 
500         
 50 1039 429 0.413 8.58 26.0 16.820 
1600         
 50 1047 554 0.529 11.08 26.0 49.705 
3000         
 50 1048 526 0.502 10.52 26.0 42.003 
4000         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1043 2086 2.000 41.72 26.0 465.854
Cyclophosphamide 
2         
 50 1043 1930 1.850 38.60 26.0 423.537
Trend: 6.298        
Probability: 0.000