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Study Information
Study Attribute Value
CEBS Accession Number: 002-02454-0001-0000-8
Chemical Name: Methyl viologen
CASRN: 1910-42-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 540279
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 72 90 138 64 49
    94 96 102 36
    92 108 129 47
    83 106 126 51
Test Chemical Methyl viologen 
100         
 66 21 298 151 144*
    51 20 211 137
  
125         
 66r 17 339 172
    51 16 145 95
  
150         
 46 11 231 169 168*
    39 12 193 167
  
175         
 39 6 268 227 219*
    33 8 207 210
  
200         
 38 6 356 315 272*
    36 6 245 229
Positive Control Methyl Methane Sulfonate 
15         
 40 38 124 103 110*
    55 46 195 117

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 103 94 254 82 69
    107 96 191 60
    123r 103 203 55
    103 110 204 66
Test Chemical Methyl viologen 
10         
 100 86 257 86 84
    94 69 232 82
  
20         
 94 52 286 101 92
    91 52 225 82
  
60         
 66 18 1695 858 924*
    57 15 1698 990
  
100         
 51 8 2729 1790 1924*
    40 6 2450 2059
  
140         
   
Positive Control Methyl Methane Sulfonate 
15         
 49 25 581 394 382*
    44 19 487 370

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination