Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02454-0001-0000-8
Chemical Name:	Methyl viologen
CASRN:	1910-42-5
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	540279
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	72	90	138	64	49
			94	96	102	36
			92	108	129	47
			83	106	126	51
Test Chemical	Methyl viologen	100	66	21	298	151	144*
			51	20	211	137	144*
		125	66r	17	339	172
			51	16	145	95
		150	46	11	231	169	168*
			39	12	193	167	168*
		175	39	6	268	227	219*
			33	8	207	210	219*
		200	38	6	356	315	272*
			36	6	245	229	272*
Positive Control	Methyl Methane Sulfonate	15	40	38	124	103	110*
Positive Control			55	46	195	117	110*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	103	94	254	82	69
			107	96	191	60
			123r	103	203	55
			103	110	204	66
Test Chemical	Methyl viologen	10	100	86	257	86	84
			94	69	232	82	84
		20	94	52	286	101	92
			91	52	225	82	92
		60	66	18	1695	858	924*
			57	15	1698	990	924*
		100	51	8	2729	1790	1924*
			40	6	2450	2059	1924*
		140

Positive Control	Methyl Methane Sulfonate	15	49	25	581	394	382*
Positive Control			44	19	487	370	382*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination