Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02459-0002-0000-4
Chemical Name:	Methylamine
CASRN:	74-89-5
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	631545
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	101	62	112	37	38
			86	117	103	40
			103	123	111	36
			106	98	122	38
Test Chemical	Methylamine	50	83	82	114	46	36
			77	76	70	30
			55	64	51	31
		100	62	39	93	50	51
			67	95	107	53
			69	74	102	50
		150	87	96	68	26	33
			67	87	71	35
			86	93	99	39
		200	105	83	145	46	42
			93	81	148	53
			85	60	68	27
		300	71	42	119	56	57*
			103#	56	128	41
			82	54	181	73
Positive Control	Methyl Methane Sulfonate	5	41	37	624	509	458*
			51	29	462	301
			36	24	607	565

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	64	92	115	60	41
			96	85	127	44
			105	123	64	20
			43r	44	113	89
Test Chemical	Methylamine	25	63	101	102	54	52
			100	169	107	36
			70	68	138	66
		50	51	85	91	60	61
			59	112	87	49
			54	80	117	72
		100	51#	99	106	69	57
			112	159	169	50
			114	57	178	52
		200	47	79	119	84	67*
			52	76	122	78
			99	147	116	39
Positive Control	Methyl Methane Sulfonate	5	35	24	253	243	356*
			43	23	611	477
			40	54	413	349

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination