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Study Information
Study Attribute Value
CEBS Accession Number: 002-02459-0002-0000-4
Chemical Name: Methylamine
CASRN: 74-89-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 631545
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 101 62 112 37 38
    86 117 103 40
    103 123 111 36
    106 98 122 38
Test Chemical Methylamine 
50         
 83 82 114 46 36
    77 76 70 30
    55 64 51 31
  
100         
 62 39 93 50 51
    67 95 107 53
    69 74 102 50
  
150         
 87 96 68 26 33
    67 87 71 35
    86 93 99 39
  
200         
 105 83 145 46 42
    93 81 148 53
    85 60 68 27
  
300         
 71 42 119 56 57*
    103# 56 128 41
    82 54 181 73
Positive Control Methyl Methane Sulfonate 
5         
 41 37 624 509 458*
    51 29 462 301
    36 24 607 565

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 64 92 115 60 41
    96 85 127 44
    105 123 64 20
    43r 44 113 89
Test Chemical Methylamine 
25         
 63 101 102 54 52
    100 169 107 36
    70 68 138 66
  
50         
 51 85 91 60 61
    59 112 87 49
    54 80 117 72
  
100         
 51# 99 106 69 57
    112 159 169 50
    114 57 178 52
  
200         
 47 79 119 84 67*
    52 76 122 78
    99 147 116 39
Positive Control Methyl Methane Sulfonate 
5         
 35 24 253 243 356*
    43 23 611 477
    40 54 413 349

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination