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Study Information
Study Attribute Value
CEBS Accession Number: 002-02466-0005-0000-5
Chemical Name: Methylenedianiline
CASRN: 101-77-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 535562_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/06/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 4.25 ± 0.398
Test Chemical Methylenedianiline 
50         
 4 6.72 ± 0.730
  
100         
 4 4.70 ± 0.715
  
200         
 4 4.17 ± 0.170
Positive Control Dimethylbenzanthracene 
2.5       
 4 7.82 ± 0.612


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 09/30/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 3.90 ± 0.774
Test Chemical Methylenedianiline 
50         
 4 4.95 ± 0.319
  
100         
 4 5.28 ± 0.186
  
200         
 4 6.35 ± 0.792
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.73 ± 0.984


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 09/06/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 4.97 ± 0.517
Test Chemical Methylenedianiline 
35         
 4 3.73 ± 0.230
  
70         
 4 3.41 ± 0.349
  
140         
 4 6.44 ± 0.372
Positive Control Dimethylbenzanthracene 
50         
 4 16.33 ± 1.202


Summary of Sister Chromatid Exchange Data (Trial 4)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 10/11/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 4.39 ± 0.575
Test Chemical Methylenedianiline 
50         
 4 4.71 ± 0.287
  
100         
 4 5.15 ± 0.598
  
200         
 4 7.98 ± 0.370
Positive Control Dimethylbenzanthracene 
2.5       
 4 11.43 ± 1.203


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed