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Study Information
Study Attribute Value
CEBS Accession Number: 002-02466-0006-0000-6
Chemical Name: Methylenedianiline
CASRN: 101-77-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 535562_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/29/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.8484
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 14.50 ± 1.76 0.0000
Test Chemical Methylenedianiline 
50         
 8 1.75 ± 0.80 0.5000
  
100         
 8 1.25 ± 0.37 0.7196
  
200         
 8 1.00 ± 0.76 0.8188
Vehicle Control No Stressor 
 0         
 8 1.75 ± 0.59 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/31/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0004
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 24.25 ± 4.32 0.0000
Test Chemical Methylenedianiline 
50         
 8 4.25 ± 1.87 0.1721
  
100         
 8 2.50 ± 0.73 0.6673
  
200         
 8 8.00 ± 1.89 0.0010
Vehicle Control No Stressor 
 0         
 8 3.00 ± 1.00 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/07/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 23.00 ± 6.01 0.0000
Test Chemical Methylenedianiline 
100         
 8 2.00 ± 0.65 0.0645
  
150         
 8 4.25 ± 1.79 0.0008
  
200         
 8 7.50 ± 3.02 0.0000
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed