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Study Information
Study Attribute Value
CEBS Accession Number: 002-02467-0001-0000-2
Chemical Name: Methyleugenol
CASRN: 93-15-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 614248_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/23/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 367 0.352 7.34 26.0 -6.378
Dimethyl Sulfoxide 
0         
 50 1044 392 0.375 7.84 26.0 0.000
Test Chemical Methyleugenol 
5         
 50 1046 373 0.357 7.46 26.0 -5.029 
17         
 50 1039 405 0.390 8.10 26.0 3.814 
50         
 50 1044 448 0.429 8.96 26.0 14.286 
167         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1046 549 0.525 10.98 26.0 39.783
Mitomycin-C 
 0.004     
 10 210 182 0.867 18.20 26.0 130.816
Trend: 2.235        
Probability: 0.013        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/23/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 359 0.343 7.18 26.0 0.000
Negative (Not Specified) 
0         
 50 1044 367 0.352 7.34 26.0 2.522
Test Chemical Methyleugenol 
17         
 50 1048 469 0.448 9.38 26.0 30.516 
50         
 50 1045 421 0.403 8.42 26.0 17.495 
167         
 50 1044 607 0.581 12.14 26.0 69.567 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1048 675 0.644 13.50 26.0 87.843
Cyclophosphamide 
 0.5       
 10 208 204 0.981 20.40 26.0 186.035
Trend: 7.370        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/13/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 390 0.374 7.80 26.0 -1.447
Dimethyl Sulfoxide 
0         
 50 1050 398 0.379 7.96 26.0 0.000
Test Chemical Methyleugenol 
50         
 50 1047 430 0.411 8.60 26.0 8.350 
167         
 50 1047 477 0.456 9.54 26.0 20.193 
250         
 50 1048 548 0.523 10.96 26.0 37.951
Positive Control Cyclophosphamide 
 0.125     
 50 1046 588 0.562 11.76 26.0 48.304
Cyclophosphamide 
 0.5       
 10 208 207 0.995 20.70 26.0 162.551
Trend: 5.004        
Probability: 0.000