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Study Information
Study Attribute Value
CEBS Accession Number: 002-02469-0004-0000-7
Chemical Name: Methylphenidate hydrochloride
CASRN: 298-59-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 864605_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 01/18/1983    Harvest Time: 21 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Water 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Methylphenidate hydrochloride 
750         
 100 2 0.020 1.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
1000         
 84 4 0.048 4.0 4 0.048 4.0 0 0.000 0.0 0 0.000 0.0 
1250         
 100 6 0.060 5.0 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 
1500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.062     
 50 9 0.180 14.0 5 0.100 10.0 3 0.060 6.0 1 0.020 2.0
Trend: 2.077 1.387 1.742  
Probability: 0.019 0.083 0.041  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/12/1983    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Water 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Methylphenidate hydrochloride 
1000         
 100 11 0.110 8.0 1 0.010 1.0 9 0.090 7.0 1 0.010 1.0 
1250         
 100 11 0.110 9.0 4 0.040 4.0 6 0.060 5.0 1 0.010 1.0 
1500         
 100 8 0.080 8.0 3 0.030 3.0 5 0.050 5.0 0 0.000 0.0 
1750         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 50 11 0.220 18.0 7 0.140 14.0 4 0.080 6.0 0 0.000 0.0
Trend: 2.299 1.956 1.401  
Probability: 0.011 0.025 0.081