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Study Information
Study Attribute Value
CEBS Accession Number: 002-02476-0004-0000-5
Chemical Name: Michler's ketone
CASRN: 90-94-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 913588_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 11/13/1990    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: Michler's ketone 
14         
 200 5 0.025 2.5 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0 
30         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
65         
 200 5 0.025 2.5 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 58 2.320 84.0 29 1.160 68.0 19 0.760 52.0 10 0.400 4.0
Trend: 0.904 0.204 0.949  
Probability: 0.183 0.419 0.171  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/11/1990    Harvest Time: 16.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: Michler's ketone 
65         
 200 24 0.120 8.5 21 0.105 7.5 3 0.015 1.5 0 0.000 0.0 
140         
 200 37 0.185 14.0 25 0.125 9.0 12 0.060 5.5 0 0.000 0.0 
300         
 200 35 0.175 15.0 29 0.145 13.0 5 0.025 2.5 1 0.005 0.5
Positive Control: Cyclophosphamide 
20         
 25 22 0.880 64.0 15 0.600 44.0 7 0.280 24.0 0 0.000 0.0
Trend: 5.094 4.682 2.029  
Probability: 0.000 0.000 0.021  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 08/14/1990    Harvest Time: 16.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 0.5 0 0.000 0.0 3 0.015 0.5 0 0.000 0.0
Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Michler's ketone 
65         
 50 20 0.400 30.0 16 0.320 26.0 4 0.080 8.0 0 0.000 0.0 
140         
 50 29 0.580 38.0 25 0.500 34.0 4 0.080 8.0 0 0.000 0.0 
300         
 50 25 0.500 38.0 25 0.500 38.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 17 0.680 48.0 11 0.440 36.0 6 0.240 16.0 0 0.000 0.0
Trend: 8.383 8.492 1.289  
Probability: 0.000 0.000 0.099