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Study Information
Study Attribute Value
CEBS Accession Number: 002-02478-0001-0000-4
Chemical Name: Mirex
CASRN: 2385-85-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 473171_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1   
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/20/1983    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 426 0.407 8.52 26.0 0.000
Test Chemical Mirex 
26         
 50 1048 428 0.408 8.56 26.0 0.278 
83.2       
 50 1047 412 0.394 8.24 26.0 -3.379 
260         
 50 1049 451 0.430 9.02 26.0 5.566
Positive Control Mitomycin-C 
 0.005     
 50 1050 514 0.490 10.28 26.0 20.198
Trend: 0.597        
Probability: 0.275        

Trial #: 2    Activation: No Activation    Date: 08/24/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 409 0.389 8.18 26.0 0.000
Test Chemical Mirex 
26         
 50 1044 403 0.386 8.06 26.0 -0.712 
83.2       
 50 1044 314 0.301 6.28 26.0 -22.639 
260         
 50 1052 350 0.333 7.00 26.0 -14.425
Positive Control Mitomycin-C 
 0.005     
 25 526 610 1.160 24.40 26.0 198.289
Trend: -3.101        
Probability: 0.999        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/20/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 461 0.440 9.22 26.0 0.000
Test Chemical Mirex 
26         
 50 1051 475 0.452 9.50 26.0 2.645 
83.2       
 50 1047 491 0.469 9.82 26.0 6.508 
260         
 50 1052 483 0.459 9.66 26.0 4.274
Positive Control Cyclophosphamide 
1         
 25 526 443 0.842 17.72 26.0 91.277
Trend: 0.790        
Probability: 0.215