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Study Information
Study Attribute Value
CEBS Accession Number: 002-02480-0001-0000-7
Chemical Name: Molybdenum trioxide
CASRN: 1313-27-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 364562_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/06/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1022 384 0.376 7.68 26.0 -13.023
Dimethyl Sulfoxide 
0         
 50 1044 451 0.432 9.02 26.0 0.000
Test Chemical Molybdenum trioxide 
 0.5       
 50 1031 407 0.395 8.14 26.0 -8.618 
1.6       
 50 1036 435 0.420 8.70 26.0 -2.803 
5         
 50 1042 437 0.419 8.74 26.0 -2.918 
10         
 50 1023 413 0.404 8.26 26.0 -6.546
Positive Control Mitomycin-C 
 0.01      
 50 1044 3190 3.056 63.80 26.0 607.317
Trend: -0.450        
Probability: 0.674        

Trial #: 2    Activation: No Activation    Date: 07/26/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1029 465 0.452 9.30 26.0 0.000
Negative (Not Specified) 
0         
 50 1030 438 0.425 8.76 26.0 -5.898
Test Chemical Molybdenum trioxide 
5         
 50 1036 476 0.459 9.52 26.0 1.674 
7.5       
 50 1029 436 0.424 8.72 26.0 -6.237 
10         
 50 1026 465 0.453 9.30 26.0 0.292
Positive Control Mitomycin-C 
 0.01      
 50 1040 3029 2.913 60.58 26.0 544.508
Trend: -0.420        
Probability: 0.663        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/06/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 360 0.347 7.20 26.0 0.000
Negative (Not Specified) 
0         
 50 1042 452 0.434 9.04 26.0 24.833
Test Chemical Molybdenum trioxide 
 0.5       
 50 1040 397 0.382 7.94 26.0 9.854 
1.6       
 50 1042 349 0.335 6.98 26.0 -3.614 
5         
 50 1037 341 0.329 6.82 26.0 -5.369 
10         
 50 1037 359 0.346 7.18 26.0 -0.374
Positive Control Cyclophosphamide 
2         
 50 1043 1161 1.113 23.22 26.0 220.336
Trend: -1.061        
Probability: 0.856        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/26/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1023 419 0.410 8.38 26.0 0.000
Negative (Not Specified) 
0         
 50 1037 434 0.419 8.68 26.0 2.182
Test Chemical Molybdenum trioxide 
5         
 50 1021 358 0.351 7.16 26.0 -14.391 
7.5       
 50 1019 395 0.388 7.90 26.0 -5.358 
15         
 50 1042 377 0.362 7.54 26.0 -11.665
Positive Control Cyclophosphamide 
2         
 50 1037 1190 1.148 23.80 26.0 180.175
Trend: -1.334        
Probability: 0.909