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Study Information
Study Attribute Value
CEBS Accession Number: 002-02481-0001-0000-8
Chemical Name: Mono(2-ethylhexyl)adipate
CASRN: 4337-65-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 567974_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Questionable 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 05/07/1983    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 441 0.420 8.82 27.0 0.000
Negative (Not Specified) 
0         
 50 1041 444 0.427 8.88 27.0 1.647
Test Chemical Mono(2-ethylhexyl)adipate 
1.6       
 50 1044 530 0.508 10.60 27.0 20.987 
16         
 50 1043 475 0.455 9.50 27.0 8.536 
50         
 50 1046 510 0.488 10.20 27.0 16.199 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1046 1589 1.519 31.78 27.0 262.040
Trend: 1.403        
Probability: 0.080        

Trial #: 2    Activation: No Activation    Date: 06/04/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1042 399 0.383 7.98 28.0 -3.394
Dimethyl Sulfoxide 
0         
 50 1047 415 0.396 8.30 28.0 0.000
Test Chemical Mono(2-ethylhexyl)adipate 
10         
 50 1035 464 0.448 9.28 28.0 13.104 
25         
 50 1040 464 0.446 9.28 28.0 12.560 
50         
 50 1043 420 0.403 8.40 28.0 1.593 
75         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.003     
 50 1041 913 0.877 18.26 28.0 121.268
Mitomycin-C 
 0.005     
 50 1028 1216 1.183 24.32 28.0 198.428
Trend: 0.168        
Probability: 0.433        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/14/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1035 406 0.392 8.12 26.0 -6.905
Dimethyl Sulfoxide 
0         
 50 1011 426 0.421 8.52 26.0 0.000
Test Chemical Mono(2-ethylhexyl)adipate 
16         
 50 1033 360 0.348 7.20 26.0 -17.293 
50         
 50 1037 383 0.369 7.66 26.0 -12.348 
160         
 50 1022 366 0.358 7.32 26.0 -15.009 
500         
 50 1040 440 0.423 8.80 26.0 0.406 
1600         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 0 0 0 0.000 0.00 26.0 N/A
Trend: 0.250        
Probability: 0.401        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/04/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1036 430 0.415 8.60 28.0 8.716
Dimethyl Sulfoxide 
0         
 50 1032 394 0.382 7.88 28.0 0.000
Test Chemical Mono(2-ethylhexyl)adipate 
200         
 50 1044 467 0.447 9.34 28.0 17.166 
400         
 50 1044 484 0.464 9.68 28.0 21.431 
500         
 50 1045 487 0.466 9.74 28.0 22.066 
750         
 50 1047 474 0.453 9.48 28.0 18.581 
1000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1040 1446 1.390 28.92 28.0 264.182
Trend: 2.581        
Probability: 0.005