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Study Information
Study Attribute Value
CEBS Accession Number: 002-02482-0003-0000-1
Chemical Name: Mono(2-ethylhexyl)phthalate
CASRN: 4376-20-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 898004_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/03/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1037 466 0.449 9.32 26.0 0.000
Test Chemical Mono(2-ethylhexyl)phthalate 
5         
 50 1036 389 0.375 7.78 26.0 -16.443 
16.7       
 50 1035 424 0.410 8.48 26.0 -8.837 
50         
 50 1034 421 0.407 8.42 26.0 -9.395 
167         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1018 663 0.651 13.26 26.0 44.930
Mitomycin-C 
 0.01      
 5 102 194 1.902 38.80 26.0 323.247
Trend: -1.045        
Probability: 0.852        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/03/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1023 421 0.412 8.42 26.0 0.000
Test Chemical Mono(2-ethylhexyl)phthalate 
5         
 50 1028 418 0.407 8.36 26.0 -1.196 
16.7       
 50 1041 437 0.420 8.74 26.0 2.006 
50         
 50 1016 417 0.410 8.34 26.0 -0.268 
167         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1007 592 0.588 11.84 26.0 42.852
Cyclophosphamide 
2         
 5 109 187 1.716 37.40 26.0 316.878
Trend: 0.120        
Probability: 0.452