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Study Information
Study Attribute Value
CEBS Accession Number: 002-02485-0001-0000-2
Chemical Name: Monochloroacetic acid
CASRN: 79-11-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 265221_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/18/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1042 383 0.368 7.66 26.0 0.000
Test Chemical Monochloroacetic acid 
50         
 50 1047 436 0.416 8.72 26.0 13.294 
160         
 50 1046 519 0.496 10.38 26.0 34.991 
500         
 50 1049 572 0.545 11.44 28.0 48.351
Positive Control Triethylenemelamine 
 0.015     
 50 1050 1442 1.373 28.84 26.0 273.633
Trend: 6.561        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/18/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1042 408 0.392 8.16 26.0 0.000
Test Chemical Monochloroacetic acid 
50         
 50 1045 424 0.406 8.48 26.0 3.623 
160         
 50 1042 428 0.411 8.56 26.0 4.902 
500         
 50 1046 423 0.404 8.46 26.0 3.280 
1600         
 50 1051 479 0.456 9.58 26.0 16.397
Positive Control Cyclophosphamide 
1         
 50 1046 910 0.870 18.20 26.0 122.186
Trend: 2.026        
Probability: 0.021