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Study Information
Study Attribute Value
CEBS Accession Number: 002-02485-0010-0000-2
Chemical Name: Monochloroacetic acid
CASRN: 79-11-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 486223
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 79 104 106 45 40
    80 107 68 28
    82 96 91 37
    93 93 136 49
Test Chemical Monochloroacetic acid 
50         
 84 85 123 49 46
    94 81 121 43
  
100         
 112 75 135 40 38
    83 77 88 35
  
200         
 89 75 127 47 60
    84 74 181 72
  
400         
 55 15 149 90 122*
    52 15 239 153
  
800         
 80 28 218 90 114*
    67 19 275 137
Positive Control Ethyl Methane Sulfonate 
250         
 66 58 688 347 325*
    76 62 688 302

Nonactivation Trial: 2 Experiment Call: Inconclusive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 71 93 84 40 46
    71 88 97 46
    56 113 80 48
    61 106 93 51
Test Chemical Monochloroacetic acid 
31.25      
 57 79 112 66 55
    66 100 88 45
  
62.5       
 61 98 97 53 56
    49 82 86 59
  
125         
 44 66 85 64 51
    100 91 116 39
  
250         
 77 73 141 61 59
    64 59 108 57
  
500         
   
Positive Control Ethyl Methane Sulfonate 
250         
 70 74 683 327 331*
    50 56 499 336

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 90 125 200 74 69
    81 98 185 77
    93 91 155 56
    76 87 157 69
Test Chemical Monochloroacetic acid 
100         
 77 80 166 72 75
    75 82 170 76
    77 77 178 77
  
200         
 73 62 220 101 93
    73 56 184 84
    76 51 214 94
  
400         
 184*
    50 7 299 198
    62 8 315 171
  
600         
   
   
Positive Control Ethyl Methane Sulfonate 
250         
 66 81 609 306 288*
    84 64 685 271

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination