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Study Information
Study Attribute Value
CEBS Accession Number: 002-02492-0001-0000-0
Chemical Name: Monuron
CASRN: 150-68-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 030952_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1   
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/29/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 514 213 0.414 8.52 25.5 0.000
Test Chemical Monuron 
100         
 25 511 225 0.440 9.00 25.5 6.254 
333         
 0 0 0 0.000 0.00 0.0 N/A
Trend: 0.635        
Probability: 0.263        

Trial #: 2    Activation: No Activation    Date: 07/19/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 496 0.482 9.92 25.5 0.000
Test Chemical Monuron 
50         
 50 1028 557 0.542 11.14 36.3 12.298 
100         
 50 1014 608 0.600 12.16 36.3 24.273 
200         
 50 1019 608 0.597 12.16 36.3 23.663
Positive Control Mitomycin-C 
 0.005     
 25 517 816 1.578 32.64 25.5 227.123
Trend: 3.845        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/29/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 454 0.440 9.08 25.5 0.000
Test Chemical Monuron 
100         
 50 1030 515 0.500 10.30 25.5 13.656 
333         
 50 1037 475 0.458 9.50 25.5 4.121 
1000         
 50 1035 536 0.518 10.72 25.5 17.719
Positive Control Cyclophosphamide 
1.5       
 25 517 790 1.528 31.60 25.5 247.344
Trend: 1.965        
Probability: 0.025        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/19/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1029 484 0.470 9.68 25.5 0.000
Test Chemical Monuron 
1200         
 50 1019 611 0.600 12.22 25.5 27.479 
1400         
 50 1017 640 0.629 12.80 37.3 33.792 
1500         
 50 1022 630 0.616 12.60 37.3 31.057
Positive Control Cyclophosphamide 
1.5       
 25 515 853 1.656 34.12 25.5 252.137
Trend: 4.554        
Probability: 0.000