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Study Information
Study Attribute Value
CEBS Accession Number: 002-02492-0002-0000-1
Chemical Name: Monuron
CASRN: 150-68-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 030952_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 08/02/1982    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0
Test Chemical: Monuron 
800         
 100 7 0.070 6.0 4 0.040 4.0 2 0.020 2.0 1 0.010 1.0 
900         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1000         
 100 5 0.050 4.0 4 0.040 4.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.01      
 50 5 0.100 8.0 2 0.040 4.0 2 0.040 2.0 1 0.020 2.0
Trend: -0.044 0.712 0.236  
Probability: 0.517 0.238 0.407  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/22/1982    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 2.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Monuron 
1300         
 100 37 0.370 19.0 14 0.140 9.0 8 0.080 7.0 15 0.150 1.0 
1400         
 100 17 0.170 10.0 9 0.090 7.0 6 0.060 4.0 2 0.020 2.0 
1500         
 100 4 0.040 4.0 4 0.040 4.0 0 0.000 0.0 0 0.000 0.0 
1600         
 100 3 0.030 2.0 3 0.030 2.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2         
 50 1 0.020 2.0 1 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Trend: -1.582 -0.430 -1.503  
Probability: 0.943 0.667 0.934