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Study Information
Study Attribute Value
CEBS Accession Number: 002-02504-0002-0000-5
Chemical Name: N,N'-Diethylthiourea
CASRN: 105-55-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 481340_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/23/1983    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: N,N'-Diethylthiourea 
160         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
500         
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
1600         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 13 0.260 24.0 4 0.080 8.0 9 0.180 16.0 0 0.000 0.0
Trend: 0.103 0.253 0.000  
Probability: 0.459 0.400 0.500  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/23/1983    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 5 0.050 4.0 0 0.000 0.0 5 0.050 4.0 0 0.000 0.0
Test Chemical: N,N'-Diethylthiourea 
500         
 100 7 0.070 5.0 0 0.000 0.0 7 0.070 5.0 0 0.000 0.0 
1600         
 100 8 0.080 8.0 3 0.030 3.0 5 0.050 5.0 0 0.000 0.0 
5000         
 100 8 0.080 8.0 3 0.030 3.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 19 0.380 30.0 4 0.080 8.0 15 0.300 24.0 0 0.000 0.0
Trend: 1.388 2.211 0.316  
Probability: 0.083 0.014 0.376