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Study Information
Study Attribute Value
CEBS Accession Number: 002-02505-0002-0000-6
Chemical Name: N,N'-Diphenyl-p-phenylenediamine
CASRN: 74-31-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 494928_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 01/09/1986    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: N,N'-Diphenyl-p-phenylenediamine 
10         
 200 7 0.035 4.0 2 0.010 1.0 5 0.025 3.0 0 0.000 0.0 
16         
 200 3 0.015 2.0 0 0.000 0.0 3 0.015 2.0 0 0.000 0.0 
30         
 200 8 0.040 4.0 1 0.005 1.0 7 0.035 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.063     
 200 22 0.110 9.0 8 0.040 4.0 14 0.070 6.0 0 0.000 0.0
Mitomycin-C 
 0.125     
 50 11 0.220 22.0 4 0.080 8.0 7 0.140 14.0 0 0.000 0.0
Trend: 1.414 -0.291 1.671  
Probability: 0.079 0.614 0.047  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/09/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: N,N'-Diphenyl-p-phenylenediamine 
50         
 200 5 0.025 3.0 0 0.000 0.0 5 0.025 3.0 0 0.000 0.0 
100         
 200 3 0.015 2.0 0 0.000 0.0 3 0.015 2.0 0 0.000 0.0 
160         
 200 5 0.025 3.0 0 0.000 0.0 5 0.025 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 45 0.225 17.0 16 0.080 7.0 19 0.095 9.0 10 0.050 1.0
Cyclophosphamide 
7.5       
 50 22 0.440 28.0 5 0.100 8.0 17 0.340 26.0 0 0.000 0.0
Trend: 1.023 0.000 1.023  
Probability: 0.153 0.000 0.153