Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02506-0002-0000-7 |
Chemical Name: | N,N'-bis(1,4-Dimethylpentyl)-p-phenylenediamine |
CASRN: | 3081-14-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 388718_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | N,N'-bis(1,4-Dimethylpentyl)-p-phenylenediamine | 5 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
10 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
16 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 49 | 0.245 | 20.5 | 23 | 0.115 | 10.5 | 26 | 0.130 | 11.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 33 | 0.660 | 46.0 | 19 | 0.380 | 26.0 | 14 | 0.280 | 26.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.874 | -0.480 | -0.751 | ||||||||||||
Probability: | 0.809 | 0.684 | 0.774 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | N,N'-bis(1,4-Dimethylpentyl)-p-phenylenediamine | 5 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
10 | 200 | 6 | 0.030 | 2.5 | 1 | 0.005 | 0.5 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 | ||
16 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 29 | 0.145 | 13.0 | 6 | 0.030 | 3.0 | 23 | 0.115 | 10.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 19 | 0.380 | 34.0 | 3 | 0.060 | 6.0 | 16 | 0.320 | 30.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.205 | -0.735 | 0.779 | ||||||||||||
Probability: | 0.419 | 0.769 | 0.218 |