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Study Information
Study Attribute Value
CEBS Accession Number: 002-02507-0002-0000-8
Chemical Name: N,N'-methylenebisacrylamide
CASRN: 110-26-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 878009_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 06/06/1989    Harvest Time: 14.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: N,N'-methylenebisacrylamide 
250         
 50 45 0.900 62.0 0 0.000 0.0 45 0.900 62.0 0 0.000 0.0 
275         
 100 55 0.550 39.0 1 0.010 1.0 54 0.540 38.0 0 0.000 0.0 
300         
 50 31 0.620 38.0 0 0.000 0.0 31 0.620 38.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 50 45 0.900 48.0 20 0.400 34.0 25 0.500 32.0 0 0.000 0.0
Trend: 8.285 0.918 8.208  
Probability: 0.000 0.179 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/25/1989    Harvest Time: 13.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: N,N'-methylenebisacrylamide 
541         
 200 11 0.055 5.0 4 0.020 2.0 7 0.035 3.5 0 0.000 0.0 
1163         
 50 24 0.480 32.0 5 0.100 10.0 19 0.380 24.0 0 0.000 0.0 
2500         
 100 28 0.280 21.0 0 0.000 0.0 28 0.280 21.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 30 0.600 52.0 17 0.340 32.0 13 0.260 26.0 0 0.000 0.0
Trend: 7.341 0.911 7.634  
Probability: 0.000 0.181 0.000  


Trial #:2   Activation: No Activation    Date: 04/25/1989    Harvest Time: 14.3 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: N,N'-methylenebisacrylamide 
54         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
116         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
250         
 50 32 0.640 42.0 1 0.020 2.0 31 0.620 40.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 50 43 0.860 64.0 21 0.420 40.0 12 0.240 22.0 10 0.200 2.0
Trend: 9.073 1.950 8.847  
Probability: 0.000 0.026 0.000