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Study Information
Study Attribute Value
CEBS Accession Number: 002-02513-0001-0000-4
Chemical Name: N,N-Diethyl-p-phenylenediamine
CASRN: 93-05-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 427049_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 11/06/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 520 0.496 10.40 26.5 0.000
Test Chemical N,N-Diethyl-p-phenylenediamine 
 0.5       
 50 1051 500 0.476 10.00 26.5 -4.029 
1.6       
 50 1051 606 0.577 12.12 26.5 16.317 
5         
 50 1050 716 0.682 14.32 26.5 37.561 
16         
 50 1049 885 0.844 17.70 26.5 70.192 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 636 0.606 12.72 26.5 22.191
Mitomycin-C 
 0.005     
 10 210 278 1.324 27.80 26.5 167.053
Trend: 11.788        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 12/17/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 421 0.401 8.42 26.0 0.000
Test Chemical N,N-Diethyl-p-phenylenediamine 
3         
 50 1050 589 0.561 11.78 26.0 39.905 
5         
 50 1044 659 0.631 13.18 26.0 57.432 
10         
 50 1050 714 0.680 14.28 26.0 69.596 
16         
 50 1047 856 0.818 17.12 31.0 103.908
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 631 0.601 12.62 26.0 49.881
Mitomycin-C 
 0.005     
 10 211 370 1.754 37.00 26.0 337.347
Trend: 12.306        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/06/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 429 0.411 8.58 26.0 0.000
Test Chemical N,N-Diethyl-p-phenylenediamine 
5         
 50 1044 460 0.441 9.20 26.0 7.123 
16         
 50 1050 469 0.447 9.38 26.0 8.595 
50         
 50 1050 576 0.549 11.52 26.0 33.371 
160         
 50 1050 646 0.615 12.92 26.0 49.579 
500         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.15      
 50 1049 746 0.711 14.92 26.0 72.898
Cyclophosphamide 
 0.6       
 10 210 243 1.157 24.30 26.0 181.329
Trend: 7.518        
Probability: 0.000