Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02513-0002-0000-5 |
Chemical Name: | N,N-Diethyl-p-phenylenediamine |
CASRN: | 93-05-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 427049_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
No Activation | 2 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | N,N-Diethyl-p-phenylenediamine | 5 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
10 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
16 | 200 | 10 | 0.050 | 4.5 | 0 | 0.000 | 0.0 | 10 | 0.050 | 4.5 | 0 | 0.000 | 0.0 | ||
30 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.125 | 200 | 45 | 0.225 | 15.0 | 10 | 0.050 | 4.5 | 25 | 0.125 | 11.5 | 10 | 0.050 | 1.0 |
Trend: | 2.992 | 0.000 | 2.992 | ||||||||||||
Probability: | 0.001 | 0.000 | 0.001 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Test Chemical: | N,N-Diethyl-p-phenylenediamine | 30 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
50 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
100 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
160 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 5 | 200 | 31 | 0.155 | 14.5 | 12 | 0.060 | 5.5 | 19 | 0.095 | 9.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 11 | 0.220 | 18.0 | 7 | 0.140 | 10.0 | 4 | 0.080 | 8.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.157 | 1.409 | -0.747 | ||||||||||||
Probability: | 0.562 | 0.079 | 0.772 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | N,N-Diethyl-p-phenylenediamine | 10 | 200 | 9 | 0.045 | 4.5 | 4 | 0.020 | 2.0 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 |
16 | 200 | 38 | 0.190 | 16.5 | 36 | 0.180 | 15.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
20 | 200 | 16 | 0.080 | 6.0 | 0 | 0.000 | 0.0 | 16 | 0.080 | 6.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 28 | 0.140 | 13.0 | 12 | 0.060 | 6.0 | 16 | 0.080 | 7.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.125 | 50 | 24 | 0.480 | 26.0 | 7 | 0.140 | 6.0 | 17 | 0.340 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 4.008 | 3.172 | 2.338 | ||||||||||||
Probability: | 0.000 | 0.001 | 0.010 |