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Study Information
Study Attribute Value
CEBS Accession Number: 002-02513-0002-0000-5
Chemical Name: N,N-Diethyl-p-phenylenediamine
CASRN: 93-05-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 427049_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 01/02/1986    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: N,N-Diethyl-p-phenylenediamine 
5         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
10         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
16         
 200 10 0.050 4.5 0 0.000 0.0 10 0.050 4.5 0 0.000 0.0 
30         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 45 0.225 15.0 10 0.050 4.5 25 0.125 11.5 10 0.050 1.0
Trend: 2.992 0.000 2.992  
Probability: 0.001 0.000 0.001  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/02/1986    Harvest Time: 13.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: N,N-Diethyl-p-phenylenediamine 
30         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
50         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
100         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
160         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 31 0.155 14.5 12 0.060 5.5 19 0.095 9.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 11 0.220 18.0 7 0.140 10.0 4 0.080 8.0 0 0.000 0.0
Trend: -0.157 1.409 -0.747  
Probability: 0.562 0.079 0.772  


Trial #:2   Activation: No Activation    Date: 08/13/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: N,N-Diethyl-p-phenylenediamine 
10         
 200 9 0.045 4.5 4 0.020 2.0 5 0.025 2.5 0 0.000 0.0 
16         
 200 38 0.190 16.5 36 0.180 15.5 2 0.010 1.0 0 0.000 0.0 
20         
 200 16 0.080 6.0 0 0.000 0.0 16 0.080 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 28 0.140 13.0 12 0.060 6.0 16 0.080 7.5 0 0.000 0.0
Mitomycin-C 
 0.125     
 50 24 0.480 26.0 7 0.140 6.0 17 0.340 24.0 0 0.000 0.0
Trend: 4.008 3.172 2.338  
Probability: 0.000 0.001 0.010