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Study Information
Study Attribute Value
CEBS Accession Number: 002-02520-0001-0000-2
Chemical Name: N,N-Dimethylaniline
CASRN: 121-69-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 609568_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 08/28/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 499 0.478 9.98 26.0 0.000
Test Chemical N,N-Dimethylaniline 
29.9       
 50 1042 441 0.423 8.82 26.0 -11.369 
99.5       
 50 1052 447 0.425 8.94 26.0 -11.017 
299         
 50 1038 530 0.511 10.60 26.0 6.929
Positive Control Mitomycin-C 
 0.002     
 50 1043 628 0.602 12.56 26.0 26.093
Mitomycin-C 
 0.01      
 10 208 317 1.524 31.70 26.0 219.162
Trend: 1.027        
Probability: 0.152        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/21/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 462 0.444 9.24 26.0 0.000
Test Chemical N,N-Dimethylaniline 
101         
 50 1039 982 0.945 19.64 26.0 112.963 
302         
 50 1043 1066 1.022 21.32 26.0 130.293 
1010         
 50 1037 1254 1.209 25.08 26.0 172.476
Positive Control Cyclophosphamide 
 0.5       
 50 1043 852 0.817 17.04 26.0 84.062
Cyclophosphamide 
2.5       
 10 210 400 1.905 40.00 26.0 329.190
Trend: 17.990        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/11/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 441 0.420 8.82 25.5 0.000
Test Chemical N,N-Dimethylaniline 
10         
 50 1045 510 0.488 10.20 25.5 16.310 
30         
 50 1050 919 0.875 18.38 25.5 108.588 
100         
 50 1052 1427 1.356 28.54 25.5 223.275 
300         
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1048 909 0.867 18.18 25.5 106.712
Cyclophosphamide 
2.5       
 10 208 616 2.962 61.60 25.5 605.800
Trend: 26.232        
Probability: 0.000