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Study Information
Study Attribute Value
CEBS Accession Number: 002-02520-0002-0000-3
Chemical Name: N,N-Dimethylaniline
CASRN: 121-69-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 609568_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 09/13/1984    Harvest Time: 10.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: N,N-Dimethylaniline 
83         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
415         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
830         
 100 9 0.090 8.0 1 0.010 1.0 8 0.080 7.0 0 0.000 0.0
Positive Control: Mitomycin-C 
5         
 100 54 0.540 37.0 24 0.240 21.0 30 0.300 25.0 0 0.000 0.0
Trend: 2.552 1.194 2.292  
Probability: 0.005 0.116 0.011  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/13/1984    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: N,N-Dimethylaniline 
83         
 100 11 0.110 9.0 7 0.070 5.0 4 0.040 4.0 0 0.000 0.0 
415         
 100 15 0.150 15.0 6 0.060 6.0 9 0.090 9.0 0 0.000 0.0 
830         
 100 19 0.190 13.0 13 0.130 10.0 6 0.060 5.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 58 0.580 37.0 32 0.320 26.0 24 0.240 21.0 2 0.020 2.0
Trend: 3.367 3.016 2.040  
Probability: 0.000 0.001 0.021  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/20/1984    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 0 0.000 0.0 4 0.040 3.0 0 0.000 0.0
Test Chemical: N,N-Dimethylaniline 
505         
 100 36 0.360 23.0 25 0.250 17.0 11 0.110 10.0 0 0.000 0.0 
755         
 100 63 0.630 35.0 39 0.390 29.0 14 0.140 10.0 10 0.100 1.0 
1010         
 100 46 0.460 27.0 18 0.180 15.0 18 0.180 15.0 10 0.100 1.0
Positive Control: Cyclophosphamide 
50         
 100 84 0.840 50.0 32 0.320 28.0 51 0.510 35.0 1 0.010 1.0
Trend: 4.676 3.753 2.709  
Probability: 0.000 0.000 0.003