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Study Information
Study Attribute Value
CEBS Accession Number: 002-02523-0001-0000-5
Chemical Name: N-(1,3-Dimethlbutyl)-N-Phenyl-P-Phenylenediamine
CASRN: 793-24-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 926819_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/14/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 499 0.477 9.98 26.0 0.000
Test Chemical N-(1,3-Dimethlbutyl)-N-Phenyl-P-Phenylenediamine 
 0.16      
 50 1046 544 0.520 10.88 26.0 9.018 
 0.5       
 50 1049 534 0.509 10.68 26.0 6.708 
1.6       
 50 1048 538 0.513 10.76 26.0 7.610 
5         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1047 630 0.602 12.60 26.0 26.132
Mitomycin-C 
 0.005     
 10 210 442 2.105 44.20 26.0 341.199
Trend: 0.996        
Probability: 0.160        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/14/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 426 0.408 8.52 26.0 0.000
Test Chemical N-(1,3-Dimethlbutyl)-N-Phenyl-P-Phenylenediamine 
 0.5       
 50 1046 413 0.395 8.26 26.0 -3.237 
1.6       
 50 1048 436 0.416 8.72 26.0 1.957 
5         
 50 1045 397 0.380 7.94 26.0 -6.897 
16         
 50 1042 498 0.478 9.96 26.0 17.126
Positive Control Cyclophosphamide 
 0.15      
 50 1046 695 0.664 13.90 26.0 62.834
Cyclophosphamide 
 0.6       
 10 210 224 1.067 22.40 26.0 161.408
Trend: 1.981        
Probability: 0.024