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Study Information
Study Attribute Value
CEBS Accession Number: 002-02524-0001-0000-6
Chemical Name: N-(1-Naphthyl)ethylenediamine dihydrochloride
CASRN: 1465-25-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 494331_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/24/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 517 0.495 10.34 25.5 0.000
Test Chemical N-(1-Naphthyl)ethylenediamine dihydrochloride 
3.3       
 50 1037 488 0.471 9.76 25.5 -4.972 
10         
 50 1030 489 0.475 9.78 25.5 -4.130 
33         
 50 1031 591 0.573 11.82 32.0 15.755 
100         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1042 696 0.668 13.92 25.5 34.881
Mitomycin-C 
 0.01      
 5 105 203 1.933 40.60 25.5 290.406
Trend: 2.446        
Probability: 0.007        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/24/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 477 0.457 9.54 25.5 0.000
Test Chemical N-(1-Naphthyl)ethylenediamine dihydrochloride 
100         
 50 1043 541 0.519 10.82 25.5 13.417 
333         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 5 105 172 1.638 34.40 25.5 258.183
Trend: 2.006        
Probability: 0.022        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/15/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 453 0.436 9.06 24.3 0.000
Test Chemical N-(1-Naphthyl)ethylenediamine dihydrochloride 
225         
 50 1042 598 0.574 11.96 24.3 31.629 
250         
 50 1039 703 0.677 14.06 24.3 55.188 
300         
 50 1031 767 0.744 15.34 31.0 70.629
Positive Control Cyclophosphamide 
 0.34      
 50 1044 645 0.618 12.90 24.3 41.702
Cyclophosphamide 
2         
 5 105 187 1.781 37.40 24.3 308.479
Trend: 9.343        
Probability: 0.000