Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02524-0001-0000-6 |
Chemical Name: | N-(1-Naphthyl)ethylenediamine dihydrochloride |
CASRN: | 1465-25-4 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 494331_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Test Failure |
Induced Rat Liver S9 | 2_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1044 | 517 | 0.495 | 10.34 | 25.5 | 0.000 |
Test Chemical | N-(1-Naphthyl)ethylenediamine dihydrochloride | 3.3 | 50 | 1037 | 488 | 0.471 | 9.76 | 25.5 | -4.972 |
10 | 50 | 1030 | 489 | 0.475 | 9.78 | 25.5 | -4.130 | ||
33 | 50 | 1031 | 591 | 0.573 | 11.82 | 32.0 | 15.755 | ||
100 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1042 | 696 | 0.668 | 13.92 | 25.5 | 34.881 |
Mitomycin-C | 0.01 | 5 | 105 | 203 | 1.933 | 40.60 | 25.5 | 290.406 | |
Trend: | 2.446 | ||||||||
Probability: | 0.007 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1043 | 477 | 0.457 | 9.54 | 25.5 | 0.000 |
Test Chemical | N-(1-Naphthyl)ethylenediamine dihydrochloride | 100 | 50 | 1043 | 541 | 0.519 | 10.82 | 25.5 | 13.417 |
333 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 2 | 5 | 105 | 172 | 1.638 | 34.40 | 25.5 | 258.183 |
Trend: | 2.006 | ||||||||
Probability: | 0.022 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1039 | 453 | 0.436 | 9.06 | 24.3 | 0.000 |
Test Chemical | N-(1-Naphthyl)ethylenediamine dihydrochloride | 225 | 50 | 1042 | 598 | 0.574 | 11.96 | 24.3 | 31.629 |
250 | 50 | 1039 | 703 | 0.677 | 14.06 | 24.3 | 55.188 | ||
300 | 50 | 1031 | 767 | 0.744 | 15.34 | 31.0 | 70.629 | ||
Positive Control | Cyclophosphamide | 0.34 | 50 | 1044 | 645 | 0.618 | 12.90 | 24.3 | 41.702 |
Cyclophosphamide | 2 | 5 | 105 | 187 | 1.781 | 37.40 | 24.3 | 308.479 | |
Trend: | 9.343 | ||||||||
Probability: | 0.000 |