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Study Information
Study Attribute Value
CEBS Accession Number: 002-02524-0002-0000-7
Chemical Name: N-(1-Naphthyl)ethylenediamine dihydrochloride
CASRN: 1465-25-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 494331_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/01/1983    Harvest Time: 20.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 4 0.040 4.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: N-(1-Naphthyl)ethylenediamine dihydrochloride 
50         
 200 21 0.105 8.0 8 0.040 3.0 13 0.065 3.0 0 0.000 0.0 
60         
 200 21 0.105 8.0 3 0.015 2.0 17 0.085 6.0 1 0.005 0.5 
70         
 150 20 0.133 10.0 3 0.020 2.0 16 0.107 7.0 1 0.007 1.0 
80         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.065     
 50 26 0.520 28.0 18 0.360 24.0 8 0.160 8.0 0 0.000 0.0
Trend: 1.276 -1.102 2.618  
Probability: 0.101 0.865 0.004  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/14/1983    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: N-(1-Naphthyl)ethylenediamine dihydrochloride 
150         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
200         
 100 15 0.150 11.0 8 0.080 8.0 7 0.070 4.0 0 0.000 0.0 
250         
 100 12 0.120 10.0 5 0.050 5.0 7 0.070 7.0 0 0.000 0.0 
300         
 50 14 0.280 16.0 5 0.100 10.0 6 0.120 12.0 3 0.060 6.0
Positive Control: Cyclophosphamide 
20         
 25 22 0.880 48.0 9 0.360 28.0 13 0.520 40.0 0 0.000 0.0
Trend: 3.188 2.908 2.379  
Probability: 0.001 0.002 0.009  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 03/23/1983    Harvest Time: 11 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: N-(1-Naphthyl)ethylenediamine dihydrochloride 
300         
 100 5 0.050 3.0 2 0.020 2.0 3 0.030 2.0 0 0.000 0.0 
325         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
350         
 100 12 0.120 7.0 2 0.020 2.0 10 0.100 6.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
62.5       
 50 15 0.300 24.0 10 0.200 18.0 5 0.100 10.0 0 0.000 0.0
Trend: 1.611 0.359 1.926  
Probability: 0.054 0.360 0.027