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Study Information
Study Attribute Value
CEBS Accession Number: 002-02538-0002-0000-2
Chemical Name: N-Ethyl-N-nitrosourea
CASRN: 759-73-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 226054_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 12/09/1987    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: N-Ethyl-N-nitrosourea 
160         
 200 121 0.605 45.5 47 0.235 21.0 74 0.370 34.0 0 0.000 0.0 
500         
 50 76 1.520 76.0 35 0.700 54.0 41 0.820 48.0 0 0.000 0.0 
1000         
 50 367 7.340 98.0 49 0.980 52.0 108 2.160 52.0 210 4.200 21.0 
1600         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 37 0.185 17.5 6 0.030 3.0 31 0.155 14.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 21 0.420 36.0 4 0.080 8.0 17 0.340 28.0 0 0.000 0.0
Trend: 14.732 10.802 9.212  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/09/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: N-Ethyl-N-nitrosourea 
500         
 50 91 1.820 90.0 48 0.960 66.0 43 0.860 64.0 0 0.000 0.0 
1000         
 50 212 4.240 100.0 82 1.640 74.0 70 1.400 80.0 60 1.200 6.0 
1600         
 50 347 6.940 100.0 70 1.400 60.0 77 1.540 58.0 200 4.000 20.0
Positive Control: Cyclophosphamide 
2.5       
 200 43 0.215 20.0 11 0.055 5.5 32 0.160 15.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 21 0.420 34.0 8 0.160 16.0 13 0.260 22.0 0 0.000 0.0
Trend: 16.476 11.854 11.866  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 01/12/1988    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: N-Ethyl-N-nitrosourea 
300         
 50 46 0.920 64.0 22 0.440 42.0 24 0.480 38.0 0 0.000 0.0 
500         
 50 68 1.360 74.0 18 0.360 32.0 50 1.000 64.0 0 0.000 0.0 
1000         
 50 457 9.140 100.0 13 0.260 14.0 84 1.680 28.0 360 7.200 36.0
Positive Control: Mitomycin-C 
 0.0625    
 200 25 0.125 12.5 5 0.025 2.5 20 0.100 10.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 21 0.420 36.0 4 0.080 6.0 17 0.340 32.0 0 0.000 0.0
Trend: 14.973 5.085 7.607  
Probability: 0.000 0.000 0.000