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Study Information
Study Attribute Value
CEBS Accession Number: 002-02542-0001-0000-6
Chemical Name: N-Isopropyl-N'-phenyl-p-phenylenediamine
CASRN: 101-72-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 042763_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 01/21/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 493 0.473 9.86 26.0 0.000
Test Chemical N-Isopropyl-N'-phenyl-p-phenylenediamine 
 0.05      
 50 1039 478 0.460 9.56 26.0 -2.763 
 0.16      
 50 1041 466 0.448 9.32 26.0 -5.386 
 0.5       
 50 1040 524 0.504 10.48 26.0 6.492 
1.6       
 50 1038 642 0.618 12.84 26.0 30.725 
5         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1043 632 0.606 12.64 26.0 28.072
Mitomycin-C 
 0.005     
 10 211 346 1.640 34.60 26.0 246.589
Trend: 4.816        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 02/26/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 455 0.435 9.10 26.0 0.000
Test Chemical N-Isopropyl-N'-phenyl-p-phenylenediamine 
1         
 50 1047 557 0.532 11.14 26.0 22.418 
1.6       
 50 1046 621 0.594 12.42 26.0 36.614 
3         
 50 1048 863 0.823 17.26 31.0 89.489 
5         
 50 1046 1067 1.020 21.34 31.0 134.730
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 603 0.575 12.06 26.0 32.401
Mitomycin-C 
 0.005     
 10 210 316 1.505 31.60 26.0 246.261
Trend: 18.250        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/21/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 384 0.366 7.68 26.0 0.000
Test Chemical N-Isopropyl-N'-phenyl-p-phenylenediamine 
 0.5       
 50 1051 417 0.397 8.34 26.0 8.387 
1.6       
 50 1044 421 0.403 8.42 26.0 10.160 
5         
 50 1051 404 0.384 8.08 26.0 5.008 
16         
 50 1049 466 0.444 9.32 26.0 21.354 
50         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.15      
 50 1052 598 0.568 11.96 26.0 55.285
Cyclophosphamide 
 0.6       
 10 210 212 1.010 21.20 26.0 175.779
Trend: 2.337        
Probability: 0.010