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Study Information
Study Attribute Value
CEBS Accession Number: 002-02555-0001-0000-0
Chemical Name: N-Methylolacrylamide
CASRN: 924-42-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 193375_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 08/10/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 457 0.437 9.14 25.8 0.000
Test Chemical N-Methylolacrylamide 
16.7       
 50 1045 520 0.498 10.40 25.8 13.786 
50         
 50 1046 524 0.501 10.48 25.8 14.551 
166.7       
 50 1043 589 0.565 11.78 30.8 29.131 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1051 569 0.541 11.38 25.8 23.797
Mitomycin-C 
 0.01      
 5 105 197 1.876 39.40 25.8 329.019
Trend: 3.954        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 09/14/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 525 276 0.526 11.04 25.8 0.000
Test Chemical N-Methylolacrylamide 
125         
 25 525 283 0.539 11.32 25.8 2.536 
166.7       
 25 525 372 0.709 14.88 25.8 34.783 
250         
 25 525 405 0.771 16.20 33.0 46.739 
375         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 25 525 327 0.623 13.08 25.8 18.478
Mitomycin-C 
 0.01      
 5 105 214 2.038 42.80 25.8 287.681
Trend: 5.736        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/10/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 377 0.359 7.54 25.8 0.000
Test Chemical N-Methylolacrylamide 
166.7       
 50 1050 407 0.388 8.14 25.8 7.958 
500         
 50 1049 436 0.416 8.72 25.8 15.760 
1700         
 50 1043 565 0.542 11.30 25.8 50.873 
5000         
 0 0 0 0.000 0.00 30.8 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1049 586 0.559 11.72 25.8 55.586
Cyclophosphamide 
2         
 5 103 181 1.757 36.20 25.8 389.429
Trend: 6.436        
Probability: 0.000