U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-02561-0001-0000-7
Chemical Name: N-Nitrosodimethylamine
CASRN: 62-75-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 159625_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/06/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 456 0.437 9.12 26.5 0.000
Test Chemical N-Nitrosodimethylamine 
502         
 50 1047 465 0.444 9.30 26.5 1.584 
1510         
 50 1040 474 0.456 9.48 26.5 4.247 
5020         
 50 1047 464 0.443 9.28 26.5 1.366
Positive Control Mitomycin-C 
 0.002     
 50 1048 788 0.752 15.76 26.5 71.983
Mitomycin-C 
 0.01      
 10 211 392 1.858 39.20 26.5 324.936
Trend: 0.310        
Probability: 0.378        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/06/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 471 0.451 9.42 26.0 0.000
Test Chemical N-Nitrosodimethylamine 
502         
 50 1043 1411 1.353 28.22 26.0 200.150 
1510         
 10 209 415 1.986 41.50 26.0 340.552 
5020         
 10 208 495 2.380 49.50 26.0 428.004
Positive Control Cyclophosphamide 
 0.5       
 50 1048 706 0.674 14.12 26.0 49.465
Cyclophosphamide 
2.5       
 10 209 369 1.766 36.90 26.0 291.720
Trend: 29.569        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/13/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 451 0.430 9.02 25.5 0.000
Test Chemical N-Nitrosodimethylamine 
299         
 50 1045 1179 1.128 23.58 25.5 162.670 
498         
 50 1048 1439 1.373 28.78 25.5 219.678 
996         
 10 211 358 1.697 35.80 25.5 295.015
Positive Control Cyclophosphamide 
 0.5       
 50 1043 873 0.837 17.46 25.5 94.869
Cyclophosphamide 
2.5       
 10 211 412 1.953 41.20 25.5 354.598
Trend: 23.525        
Probability: 0.000