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Study Information
Study Attribute Value
CEBS Accession Number: 002-02561-0002-0000-8
Chemical Name: N-Nitrosodimethylamine
CASRN: 62-75-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 159625_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 
Induced Rat Liver S9  3_S9  Positive 

Trial #:1   Activation: No Activation    Date: 01/03/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: N-Nitrosodimethylamine 
499         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1500         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
4990         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
5         
 50 69 1.380 46.0 11 0.220 16.0 18 0.360 26.0 40 0.800 4.0
Trend: -0.638 0.595 -0.651  
Probability: 0.738 0.276 0.742  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/03/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: N-Nitrosodimethylamine 
499         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
1500         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
4990         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 26 0.520 32.0 10 0.200 20.0 6 0.120 12.0 10 0.200 1.0
Trend: 1.457 1.374 0.747  
Probability: 0.073 0.085 0.227  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/14/1985    Harvest Time: 18 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: N-Nitrosodimethylamine 
500         
 100 4 0.040 4.0 4 0.040 4.0 0 0.000 0.0 0 0.000 0.0 
1500         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
5000         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 90 1.800 78.0 26 0.520 38.0 53 1.060 66.0 11 0.220 2.0
Trend: 1.184 -0.179 1.843  
Probability: 0.118 0.571 0.033  


Trial #:3_S9   Activation: Induced Rat Liver S9    Date: 01/23/1985    Harvest Time: 28 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: N-Nitrosodimethylamine 
501         
 100 4 0.040 2.0 2 0.020 1.0 2 0.020 2.0 0 0.000 0.0 
1500         
 100 29 0.290 18.0 21 0.210 15.0 8 0.080 6.0 0 0.000 0.0 
3510         
 100 56 0.560 24.0 25 0.250 20.0 11 0.110 9.0 20 0.200 2.0 
5010         
 100 104 1.040 38.0 37 0.370 25.0 27 0.270 19.0 40 0.400 4.0
Positive Control: Cyclophosphamide 
50         
 50 64 1.280 32.0 12 0.240 16.0 12 0.240 16.0 40 0.800 4.0
Trend: 8.235 6.744 5.217  
Probability: 0.000 0.000 0.000