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Study Information
Study Attribute Value
CEBS Accession Number: 002-02561-0003-0000-9
Chemical Name: N-Nitrosodimethylamine
CASRN: 62-75-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 551173_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 08/25/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1049 293 0.279 5.86 26.0 0.000
Test Chemical N-Nitrosodimethylamine 
 0.005     
 50 1051 323 0.307 6.46 26.0 10.029 
 0.05      
 50 1046 329 0.315 6.58 26.0 12.609 
 0.5       
 50 1046 397 0.380 7.94 26.0 35.883 
50         
 50 1047 352 0.336 7.04 26.0 20.366 
5000         
 50 1048 402 0.384 8.04 26.0 37.332
Positive Control Triethylenemelamine 
 0.025     
 50 1044 2070 1.983 41.40 26.0 609.868
Trend: 4.291        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/25/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1047 392 0.374 7.84 26.0 0.000
Test Chemical N-Nitrosodimethylamine 
 0.005     
 50 1048 390 0.372 7.80 26.0 -0.605 
 0.05      
 50 1047 384 0.367 7.68 26.0 -2.041 
 0.5       
 50 1048 426 0.406 8.52 26.0 8.570 
500         
 50 1049 508 0.484 10.16 26.0 29.345 
5000         
 26 543 1439 2.650 55.35 26.0 607.818
Positive Control Cyclophosphamide 
1.5       
 50 1045 2010 1.923 40.20 26.0 413.736
Trend: 38.197        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/16/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1047 396 0.378 7.92 26.0 0.000
Test Chemical N-Nitrosodimethylamine 
500         
 50 1046 1226 1.172 24.52 26.0 209.892 
1250         
 50 1047 1975 1.886 39.50 26.0 398.737 
2500         
 50 1048 2510 2.395 50.20 26.0 533.234 
5000         
 45 946 2829 2.990 62.87 26.0 690.666
Positive Control Cyclophosphamide 
1.5       
 50 1050 1716 1.634 34.32 26.0 332.095
Trend: 49.210        
Probability: 0.000