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Study Information
Study Attribute Value
CEBS Accession Number: 002-02561-0004-0000-0
Chemical Name: N-Nitrosodimethylamine
CASRN: 62-75-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 551173_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 08/25/1980    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: N-Nitrosodimethylamine 
 0.005     
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
 0.05      
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
 0.5       
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
50         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
500         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.25      
 100 35 0.350 25.0 12 0.120 11.0 23 0.230 19.0 0 0.000 0.0
Trend: 0.613 -1.499 1.322  
Probability: 0.270 0.933 0.093  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/25/1980    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: N-Nitrosodimethylamine 
 0.005     
 100 7 0.070 5.0 2 0.020 2.0 5 0.050 3.0 0 0.000 0.0 
 0.05      
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
 0.5       
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
50         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
5000         
 100 7 0.070 7.0 4 0.040 4.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 97 0.970 53.0 47 0.470 34.0 50 0.500 35.0 0 0.000 0.0
Trend: 1.337 1.854 0.178  
Probability: 0.091 0.032 0.429