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Study Information
Study Attribute Value
CEBS Accession Number: 002-02561-0005-0000-1
Chemical Name: N-Nitrosodimethylamine
CASRN: 62-75-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 857173_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 08/27/1980    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 369 0.352 7.38 26.0 0.000
Test Chemical N-Nitrosodimethylamine 
 0.05      
 50 1043 353 0.338 7.06 26.0 -3.969 
 0.5       
 50 1049 357 0.340 7.14 26.0 -3.436 
5         
 50 1049 378 0.360 7.56 26.0 2.244 
50         
 50 1047 380 0.363 7.60 26.0 2.981 
500         
 50 1048 402 0.384 8.04 26.0 8.839 
5000         
 50 1045 391 0.374 7.82 26.0 6.165
Positive Control Triethylenemelamine 
 0.015     
 50 1047 1709 1.632 34.18 26.0 363.144
Trend: 1.817        
Probability: 0.035        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/24/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1048 248 0.237 4.96 25.0 0.000
Test Chemical N-Nitrosodimethylamine 
 0.05      
 50 1041 495 0.476 9.90 25.0 100.939 
 0.5       
 50 1043 437 0.419 8.74 25.0 77.054 
5         
 50 1048 442 0.422 8.84 25.0 78.226 
50         
 50 1043 534 0.512 10.68 25.0 116.355 
500         
 50 1044 1487 1.424 29.74 29.0 501.894 
5000         
 50 1032 2678 2.595 53.56 31.0 996.580
Positive Control Cyclophosphamide 
2         
 50 1038 2893 2.787 57.86 29.0 1077.771
Trend: 59.213        
Probability: 0.000