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Study Information
Study Attribute Value
CEBS Accession Number: 002-02561-0006-0000-2
Chemical Name: N-Nitrosodimethylamine
CASRN: 62-75-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 857173_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 

Trial #:1   Activation: No Activation    Date: 07/25/1980    Harvest Time: 24 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0 2 0.020 2.0
Test Chemical: N-Nitrosodimethylamine 
 0.05      
 100 1 0.010 0.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
 0.5       
 100 2 0.020 1.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
5         
 100 1 0.010 2.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
50         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
500         
 100 0 0.000 1.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
5000         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.25      
 50 14 0.280 24.0 4 0.080 8.0 8 0.160 14.0 2 0.040 4.0
Triethylenemelamine 
 0.5       
 50 28 0.560 42.0 12 0.240 22.0 14 0.280 20.0 2 0.040 4.0
Trend: -1.245 -1.254 -0.354  
Probability: 0.893 0.895 0.638  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/25/1980    Harvest Time: 23.5 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: N-Nitrosodimethylamine 
 0.05      
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 
 0.5       
 100 4 0.040 3.0 2 0.020 1.0 0 0.000 0.0 2 0.020 2.0 
5         
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 
50         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
500         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
5000         
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 76 41 0.539 42.0 16 0.211 14.0 11 0.145 13.0 14 0.184 18.0
Trend: 1.628 0.637 3.142  
Probability: 0.052 0.262 0.001