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Study Information
Study Attribute Value
CEBS Accession Number: 002-02562-0002-0000-9
Chemical Name: N-Nitrosodiphenylamine
CASRN: 86-30-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 672479_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/01/1986    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: N-Nitrosodiphenylamine 
8.75      
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
26.2       
 200 5 0.025 2.5 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0 
43.8       
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
87.5       
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
131         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 75 0.375 27.5 20 0.100 10.0 45 0.225 19.5 10 0.050 1.0
Mitomycin-C 
5         
 50 24 0.480 32.0 15 0.300 24.0 9 0.180 14.0 0 0.000 0.0
Trend: 0.968 0.041 1.108  
Probability: 0.167 0.484 0.134  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/17/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 8 0.040 4.0 1 0.005 0.5 7 0.035 3.5 0 0.000 0.0
Test Chemical: N-Nitrosodiphenylamine 
153         
 200 11 0.055 4.0 6 0.030 2.5 5 0.025 2.5 0 0.000 0.0 
382         
 81 3 0.037 3.7 0 0.000 0.0 3 0.037 3.7 0 0.000 0.0 
1020         
 200 6 0.030 2.5 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 
1530         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 36 0.720 38.0 12 0.240 20.0 14 0.280 22.0 10 0.200 1.0
Trend: -1.398 -0.782 -1.190  
Probability: 0.919 0.783 0.883