Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02562-0002-0000-9 |
Chemical Name: | N-Nitrosodiphenylamine |
CASRN: | 86-30-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 672479_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | N-Nitrosodiphenylamine | 8.75 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
26.2 | 200 | 5 | 0.025 | 2.5 | 2 | 0.010 | 1.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
43.8 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
87.5 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
131 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 1 | 200 | 75 | 0.375 | 27.5 | 20 | 0.100 | 10.0 | 45 | 0.225 | 19.5 | 10 | 0.050 | 1.0 |
Mitomycin-C | 5 | 50 | 24 | 0.480 | 32.0 | 15 | 0.300 | 24.0 | 9 | 0.180 | 14.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.968 | 0.041 | 1.108 | ||||||||||||
Probability: | 0.167 | 0.484 | 0.134 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 8 | 0.040 | 4.0 | 1 | 0.005 | 0.5 | 7 | 0.035 | 3.5 | 0 | 0.000 | 0.0 |
Test Chemical: | N-Nitrosodiphenylamine | 153 | 200 | 11 | 0.055 | 4.0 | 6 | 0.030 | 2.5 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 |
382 | 81 | 3 | 0.037 | 3.7 | 0 | 0.000 | 0.0 | 3 | 0.037 | 3.7 | 0 | 0.000 | 0.0 | ||
1020 | 200 | 6 | 0.030 | 2.5 | 3 | 0.015 | 1.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
1530 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 36 | 0.720 | 38.0 | 12 | 0.240 | 20.0 | 14 | 0.280 | 22.0 | 10 | 0.200 | 1.0 |
Trend: | -1.398 | -0.782 | -1.190 | ||||||||||||
Probability: | 0.919 | 0.783 | 0.883 |